The complex pathophysiology of urolithiasis (kidney stones) and the effect of combinational drugs

Body organs are very crucial when it comes to homeostatically maintaining them. If any changes occur in their function, may lead the development of diseases body. The kidney is one functionalised that connected with ureter and urinary bladder, which basically lower part priorly controls volume various body fluids, fluid osmolality, acid-base balance, electrolyte concentrations, removal toxins. Any dis-balance function can generate a disease like renal calculi (kidney stone), chronic (CKD), polycystic (PKD), tract infections (UTI), etc. Kidney stones (KS) prevalent worldwide, affecting 15% individuals. A stone arranged into sizes be micro, macro, nano or found as mono polycrystalline forms. names two most common stones, calcium non-calcium (Uric acid struvite cysteine drug-induced KS), determined primarily by composition. Calcium commonly individuals, approximately 80% KS. This review provided recent details on symptoms, etiology, psychophysiology, management perspective.
 Keywords: disease, stone, calculi, Polycystic disease.